Synthesis and characterization of smart stimuli-responsive herbal drug-encapsulated nanoniosome particles for efficient treatment of breast cancer

Abstract Extraction from the herbs was performed using Soxhlet method. Various formula synthesized for niosomes containing extracts through thin film synthesis technique, and most efficient formulation selected. Afterwards, physicochemical properties of niosomes, including size, polydispersity index (PDI), zeta potential, morphology, encapsulation efficacy (EE%), extract release rate, non-interactive action between antibacterial cellular uptake were assessed. Finally, toxicity level to breast cancer cells compared their impact on expression p53 MCL-1 evaluated. Our data demonstrated that sensitive temperature pH. Also, Hedera Helix (Nio-HHE) sized 97.7 nm, with a potential −19.9 ± 6.7 mV, PDI 0.35, 58 2.4% showed more than Glycyrrhiza glabra (Nio-GGE) size 111 8.5 −23.5 4.5 0.113, 69 1.2% efficacy. The former system proved have affect oncogenes latter. Meanwhile, both niosomal systems an acceptable uptake, no chemical interaction observed. Furthermore, useful function confirmed by morphological assessments. herbal improves anticancer potential. We concluded Nio-HHE has significant antitumor effects Nio-GGE. Consequently, applying nano drug delivery based therapy could mitigate side resulting chemotherapy radiotherapy, offer promising perspectives treatment cancer.